Uropathogenic <i>Escherichia coli</i> Potentiates Type 1 Pilus-Induced Apoptosis by Suppressing NF-κB

Abstract excerpt

Urinary tract infections (UTIs) are among the most common inflammatory diseases. Acute UTIs are typically caused by type 1-piliated Escherichia coli and result in urothelial apoptosis, local cytokine release, and neutrophil infiltration. To examine the urothelial apoptotic response, a human urothelial cell line was incubated with various E. coli isolates and was then characterized by flow cytometry. Uropathogenic...

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