Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Germline mutation of microRNA-125a is associated with breast cancer.

Journal of medical genetics - 1 May 2009

Li W, Duan R, Kooy F, Sherman S L, Zhou W, Jin P

Abstract excerpt

MicroRNAs (miRNAs) are small non-coding RNAs that inhibit expression of specific target genes at the posttranscriptional level. MiRNAs are often found to be misregulated in human cancer, and they can act as either potent oncogenes or tumour suppressor genes. Here we show that a germline mutation in mature miR-125a is highly associated with breast cancer tumorigenesis, suggesting that miR-125a is likely to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Alleles
Share to Breast Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Mutational Analysis

Share to Gene Frequency

Share to Germ-Line Mutation

Share to MicroRNAs

Share to Nucleic Acid Conformation

Source

Identifiers

PMID: 19411564
DOI: 10.1136/jmg.2008.063123

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Germline mutation of microRNA-125a is associated with breast cancer.PMID 19411564Read ↗

A germline mutation in the miR‑125a coding region reduces miR‑125a expression and is associated with human gastric cancer.Semantic proximity Read ↗

The rs12975333 variant in the miR-125a and breast cancer risk in Germany, Italy, Australia and Spain.Semantic proximity Read ↗

Evaluation of genetic variations in miRNA-binding sites of BRCA1 and BRCA2 genes as risk factors for the development of early-onset and/or familial breast cancer.Semantic proximity Read ↗

A risk variant in an miR-125b binding site in BMPR1B is associated with breast cancer pathogenesis.Semantic proximity Read ↗

Functional study of one nucleotide mutation in pri-miR-125a coding region which related to recurrent pregnancy loss.Semantic proximity Read ↗

Single nucleotide polymorphism associated with mature miR-125a alters the processing of pri-miRNA.Semantic proximity Read ↗

Mir-125a rs12976445 is Associated with Susceptibility to Thyroid Cancer: A Case-control StudySemantic proximity Read ↗

Insertion of microRNA-125b-1, a human homologue of lin-4, into a rearranged immunoglobulin heavy chain gene locus in a patient with precursor B-cell acute lymphoblastic leukemiaSemantic proximity Read ↗

Two novel variants in the 3'UTR of the BRCA1 gene in familial breast and/or ovarian cancer.Semantic proximity Read ↗

A Single Variant in Pri-miRNA-155 Associated with Susceptibility to Hereditary Breast Cancer Promotes Aggressiveness in Breast Cancer Cells.Semantic proximity Read ↗

miR-125b targets erythropoietin and its receptor and their expression correlates with metastatic potential and ERBB2/HER2 expressionSemantic proximity Read ↗

rs78378222 polymorphism in the 3'-untranslated region of TP53 contributes to development of age-associated cataracts by modifying microRNA-125b-induced apoptosis of lens epithelial cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.