Article
A germline mutation in the miR‑125a coding region reduces miR‑125a expression and is associated with human gastric cancer.
Molecular medicine reports - 1 Oct 2014
Shang Hua, Wang Tao, Shang Feng, Huang Kun-Ming, Li Yan-Qing
Abstract excerpt
MicroRNAs (miRNAs) are small non-coding RNAs that inhibit the expression of target protein-coding genes, most often at the post-transcriptional level. miRNAs are often found to be misregulated in human cancer and they can act as potent oncogenes or tumor suppressor genes. In this study, we found that a germline mutation in the miR-125a coding region is associated with human gastric cancer. This mutation reduced...
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