HIV-1 clade C env clones obtained from an Indian patient exhibiting expanded coreceptor tropism are presented with naturally occurring unusual amino acid substitutions in V3 loop.

Abstract excerpt

HIV-1 subtype C is predominantly circulating in India and has been reported to be strictly CCR5 tropic irrespective of disease stages. In the present study, we examined env clones obtained from a late stage Indian patient with a history of multiple sexual partners and opportunistic infections for coreceptor usage and V3 loop sequence. The env clones were found to exploit several coreceptors in addition to CCR5 in...

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