Article
Highly complex neutralization determinants on a monophyletic lineage of newly transmitted subtype C HIV-1 Env clones from India.
Virology - 15 Mar 2009
Kulkarni Smita S, Lapedes Alan, Tang Haili, Gnanakaran S, Daniels Marcus G, Zhang Ming, Bhattacharya Tanmoy, Li Ming, Polonis Victoria R, McCutchan Francine E, Morris Lynn, Ellenberger Dennis, Butera Salvatore T, Bollinger Robert C, Korber Bette T, Paranjape Ramesh S, Montefiori David C
Abstract excerpt
Little is known about the neutralization properties of HIV-1 in India to optimally design and test vaccines. For this reason, a functional Env clone was obtained from each of ten newly acquired, heterosexually transmitted HIV-1 infections in Pune, Maharashtra. These clones formed a phylogenetically distinct genetic lineage within subtype C. As Env-pseudotyped viruses the clones were mostly resistant to IgG1b12,...
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