Article
Effect of apolipoprotein E polymorphism and XbaI polymorphism of apolipoprotein B on response to lovastatin treatment in familial and non-familial hypercholesterolaemia.
Journal of internal medicine - 1 Nov 1991
Ojala J P, Helve E, Ehnholm C, Aalto-Setälä K, Kontula K K, Tikkanen M J
Abstract excerpt
Despite the well-documented efficacy of lovastatin, a wide inter-individual variation in treatment responses has been observed. The aim of the present study was to investigate the possible roles of apolipoprotein E (apo E) phenotype and apolipoprotein B (apo B) XbaI genotype on this variation. Th...
Topics
- Adult
- Aged
- Apolipoproteins B
- Apolipoproteins E
- Deoxyribonucleases, Type II Site-Specific
- Female
- Genotype
- Humans
- Hypercholesterolemia
- Hyperlipoproteinemia Type II
- Lovastatin
- Male
- Middle Aged
- Phenotype
- Polymorphism, Genetic