Effect of apolipoprotein E and A-IV phenotypes on the low density lipoprotein response to HMG CoA reductase inhibitor therapy.

doi:10.1016/0021-9150(94)05439-p

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Article

Effect of apolipoprotein E and A-IV phenotypes on the low density lipoprotein response to HMG CoA reductase inhibitor therapy.

Atherosclerosis - 1 Mar 1995

Ordovas J M, Lopez-Miranda J, Perez-Jimenez F, Rodriguez C, Park J S, Cole T, Schaefer E J

Abstract excerpt

Our purpose was to assess the effect of apolipoprotein (apo) E and apo A-IV isoform variation on low density lipoprotein (LDL) cholesterol lowering response to the HMG CoA reductase inhibitor, pravastatin. Plasma samples were obtained from participants (apo E, n = 97; apo A-IV, n = 144) in the PL...

Topics

Alleles
Apolipoproteins A
Apolipoproteins E
Double-Blind Method
Female
Heterozygote
Homozygote
Humans
Hydroxymethylglutaryl CoA Reductases
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Hyperlipoproteinemia Type II
Lipoproteins, LDL
Male
Middle Aged

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Polymorphism, Genetic

Pravastatin

Source

Open in PubMed

Identifiers

PMID: 7605354
DOI: 10.1016/0021-9150(94)05439-p

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7605354-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.