Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An altered phenotype in a conditional knockout of Pitx2 in extraocular muscle.

Investigative ophthalmology & visual science - 1 Oct 2009

Zhou Yuefang, Cheng Georgiana, Dieter Lisa, Hjalt Tord A, Andrade Francisco H, Stahl John S, Kaminski Henry J

Abstract excerpt

PURPOSE: To determine the temporal and spatial expression of Pitx2, a bicoid-like homeobox transcription factor, during postnatal development of mouse extraocular muscle and to evaluate its role in the growth and phenotypic maintenance of postnatal extraocular muscle. METHODS: Mouse extraocular muscles of different ages were examined for the expression of Pitx2 by RT-PCR, q-PCR, and immunostaining. A conditional...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Eye Movements
Share to Fluorescent Antibody Technique, Indirect

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Homeobox Protein PITX2

Share to Homeodomain Proteins

Share to Microscopy, Fluorescence

Share to Myosins

Share to Oculomotor Muscles

Share to Protein Isoforms

Source

Open in PubMed Open full text

Identifiers

PMID: 19407022
DOI: 10.1167/iovs.08-2950
PMCID: PMC4330467

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An altered phenotype in a conditional knockout of Pitx2 in extraocular muscle.PMID 19407022Read ↗

The role of Pitx2 in maintaining the phenotype of myogenic precursor cells in the extraocular muscles.Semantic proximity Read ↗

Spatial and temporal patterns of myosin heavy chain expression in developing rat extraocular muscle.Semantic proximity Read ↗

Extraocular Muscle: Cellular Adaptations for a Diverse Functional RepertoireSemantic proximity Read ↗

pitx2 Deficiency results in abnormal ocular and craniofacial development in zebrafish.Semantic proximity Read ↗

Cranial muscle defects of Pitx2 mutants result from specification defects in the first branchial arch.Semantic proximity Read ↗

Mutations in zebrafish pitx2 model congenital malformations in Axenfeld-Rieger syndrome but do not disrupt left-right placement of visceral organs.Semantic proximity Read ↗

Otx2 gene deletion in adult mouse retina induces rapid RPE dystrophy and slow photoreceptor degeneration.Semantic proximity Read ↗

The development of longitudinal variation of Myosin isoforms in the orbital fibers of extraocular muscles of rats.Semantic proximity Read ↗

Pitx2 promotes development of splanchnic mesoderm-derived branchiomeric muscle.Semantic proximity Read ↗

PITX genes are required for cell survival and Lhx3 activation.Semantic proximity Read ↗

Zebrafish pitx3 is necessary for normal lens and retinal development.Semantic proximity Read ↗

Development of Extraocular Muscles Requires Early Signals From Periocular Neural Crest and the Developing EyeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.