Article
An altered phenotype in a conditional knockout of Pitx2 in extraocular muscle.
Investigative ophthalmology & visual science - 1 Oct 2009
Zhou Yuefang, Cheng Georgiana, Dieter Lisa, Hjalt Tord A, Andrade Francisco H, Stahl John S, Kaminski Henry J
Abstract excerpt
PURPOSE: To determine the temporal and spatial expression of Pitx2, a bicoid-like homeobox transcription factor, during postnatal development of mouse extraocular muscle and to evaluate its role in the growth and phenotypic maintenance of postnatal extraocular muscle. METHODS: Mouse extraocular muscles of different ages were examined for the expression of Pitx2 by RT-PCR, q-PCR, and immunostaining. A conditional...
Topics
- Animals
- Eye Movements
- Female
- Fluorescent Antibody Technique, Indirect
- Gene Expression Regulation
- Homeodomain Proteins
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Microscopy, Fluorescence
- Myosins
- Oculomotor Muscles