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Article

Mutation of the Cyba gene encoding p22phox causes vestibular and immune defects in mice.

The Journal of clinical investigation - 1 Mar 2008

Nakano Yoko, Longo-Guess Chantal M, Bergstrom David E, Nauseef William M, Jones Sherri M, Bánfi Botond

Abstract excerpt

In humans, hereditary inactivation of either p22(phox) or gp91(phox) leads to chronic granulomatous disease (CGD), a severe immune disorder characterized by the inability of phagocytes to produce bacteria-destroying ROS. Heterodimers of p22(phox) and gp91(phox) proteins constitute the superoxide-producing cytochrome core of the phagocyte NADPH oxidase. In this study, we identified the nmf333 mouse strain as what...

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Identifiers

PMID: 18292807
DOI: 10.1172/JCI33835
PMCID: PMC2248803

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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