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Article

Mutation of the Cyba gene encoding p22phox causes vestibular and immune defects in mice.

The Journal of clinical investigation - 1 Mar 2008

Nakano Yoko, Longo-Guess Chantal M, Bergstrom David E, Nauseef William M, Jones Sherri M, Bánfi Botond

Abstract excerpt

In humans, hereditary inactivation of either p22(phox) or gp91(phox) leads to chronic granulomatous disease (CGD), a severe immune disorder characterized by the inability of phagocytes to produce bacteria-destroying ROS. Heterodimers of p22(phox) and gp91(phox) proteins constitute the superoxide-...

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Identifiers

PMID: 18292807
DOI: 10.1172/JCI33835
PMCID: PMC2248803

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18292807-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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