Article
Estrogen receptor polymorphism, estrogen content and idiopathic scoliosis in human: a possible genetic linkage.
The Journal of steroid biochemistry and molecular biology - 1 Aug 2009
Esposito T, Uccello R, Caliendo R, Di Martino G F, Gironi Carnevale U A, Cuomo S, Ronca D, Varriale B
Abstract excerpt
Idiopathic scoliosis (IS) is a largely diffused disease in human population but its pathogenesis is still unknown. There is a relationship between scoliotic phenotype and the patient age, since in the early stage the pathology shows a ratio of 50% between male and female teenagers. During puberty the sex ratio is 8.4/1 (female/male), suggesting a sex-conditioned manifestation of the disease. Genetic inheritance...
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