Article
Altered synchrony and connectivity in neuronal networks expressing an autism-related mutation of neuroligin 3.
Neuroscience - 4 Aug 2009
Gutierrez R C, Hung J, Zhang Y, Kertesz A C, Espina F J, Colicos M A
Abstract excerpt
The neuroligin (NL) gene family codes for brain specific cell adhesion molecules that play an important role in synaptic connectivity. Recent studies have identified NL mutations linked to patients with autism spectrum disorders (ASD). Cognitive deficits seen in autistic patients are hypothesized to arise from altered synchronicity both within and between brain regions. Here we show how the expression of...
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