Article
Normal formation of a subset of intestinal granules in Caenorhabditis elegans requires ATP-binding cassette transporters HAF-4 and HAF-9, which are highly homologous to human lysosomal peptide transporter TAP-like.
Molecular biology of the cell - 1 Jun 2009
Kawai Hiromi, Tanji Takahiro, Shiraishi Hirohisa, Yamada Mitsuo, Iijima Ryoko, Inoue Takao, Kezuka Yasuko, Ohashi Kazuaki, Yoshida Yasuo, Tohyama Koujiro, Gengyo-Ando Keiko, Mitani Shohei, Arai Hiroyuki, Ohashi-Kobayashi Ayako, Maeda Masatomo
Abstract excerpt
TAP-like (TAPL; ABCB9) is a half-type ATP-binding cassette (ABC) transporter that localizes in lysosome and putatively conveys peptides from cytosol to lysosome. However, the physiological role of this transporter remains to be elucidated. Comparison of genome databases reveals that TAPL is conse...
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