Article
Association of Single-Nucleotide Polymorphisms Rs2779249 (chr17:26128581 C>A) and Rs rs2297518 (chr17: chr17:27769571 G>A) of the NOS2 Gene with Tension-Type Headache and Arterial Hypertension Overlap Syndrome in Eastern Siberia.
Genes - 17 Feb 2023
Alyabyeva Polina V, Petrova Marina M, Dmitrenko Diana V, Garganeeva Natalia P, Chumakova Galina A, Al-Zamil Mustafa, Trefilova Vera V, Nasyrova Regina F, Shnayder Natalia A
Abstract excerpt
Inducible nitric oxide (NO) synthase (iNOS), encoded by the NOS2 gene, promotes the generation of high levels of NO to combat harmful environmental influences in a wide range of cells. iNOS can cause adverse effects, such as falling blood pressure, if overexpressed. Thus, according to some data, this enzyme is an important precursor of arterial hypertension (AH) and tension-type headache (TTH), which are the most...
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