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Article

Autoregulation by the juxtamembrane region of the human ephrin receptor tyrosine kinase A3 (EphA3).

Structure (London, England : 1993) - 1 Jun 2008

Davis Tara L, Walker John R, Loppnau Peter, Butler-Cole Christine, Allali-Hassani Abdellah, Dhe-Paganon Sirano

Abstract excerpt

Ephrin receptors (Eph) affect cell shape and movement, unlike other receptor tyrosine kinases that directly affect proliferative pathways. The kinase domain of EphA3 is activated by ephrin binding and receptor oligomerization. This activation is associated with two tyrosines in the juxtamembrane region; these tyrosines are sites of autophosphorylation and interact with the active site of the kinase to modulate...

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Share to Catalytic Domain
Share to Crystallography, X-Ray

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Homeostasis

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Share to Protein Structure, Tertiary

Share to Receptor Protein-Tyrosine Kinases

Share to Sequence Homology, Amino Acid

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Source

Identifiers

PMID: 18547520
DOI: 10.1016/j.str.2008.03.008

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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