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Mechanism of Genomic Instability in Cells Infected with the High-Risk Human Papillomaviruses

23 Apr 2009

Abstract excerpt

In HPV-related cancers, the "high-risk" human papillomaviruses (HPVs) are frequently found integrated into the cellular genome. The integrated subgenomic HPV fragments express viral oncoproteins and carry an origin of DNA replication that is capable of initiating bidirectional DNA re-replication in the presence of HPV replication proteins E1 and E2, which ultimately leads to rearrangements within the locus of the...

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PMID: 19390600
DOI: 10.1371/journal.ppat.1000397

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