Article
Novel pathologic findings associated with urinary retention in a mouse model of mucopolysaccharidosis type IIIB.
Comparative medicine - 1 Apr 2009
Gografe Sylvia I, Sanberg Paul R, Chamizo Wilfredo, Monforte Hector, Garbuzova-Davis Svitlana
Abstract excerpt
Mucopolysaccharidosis type IIIB (MPS IIIB; Sanfilippo syndrome type B) is a metabolic disorder with devastating clinical characteristics starting in early childhood and leading to premature death. A knockout mouse strain was developed that models this disease. Mice of the strain B6.129S6- Naglu(tm1Efn)/J are invaluable for investigating pathogenesis and possible treatment modalities. However, the mouse strain...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
