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Cystic fibrosis transmembrane conductance regulator and caveolin-1 regulate epithelial cell internalization of <i>Pseudomonas aeruginosa</i>

23 Apr 2009

Abstract excerpt

Patients with cystic fibrosis (CF) exhibit defective innate immunity and are susceptible to chronic lung infection with Pseudomonas aeruginosa. To investigate the molecular bases for the hypersusceptibility of CF patients to P. aeruginosa, we used the IB3-1 cell line with two defective CF transmembrane conductance regulator (CFTR) genes (DeltaF508/W1282X) to generate isogenic stable, clonal lung epithelial cells...

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PMID: 19386787
DOI: 10.1152/ajpcell.00527.2008

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