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A systems-level approach to mapping the telomere length maintenance gene circuitry.

Molecular systems biology - 1 Jan 2008

Shachar Rafi, Ungar Lior, Kupiec Martin, Ruppin Eytan, Sharan Roded

Abstract excerpt

The ends of eukaryotic chromosomes are protected by telomeres, nucleoprotein structures that are essential for chromosomal stability and integrity. Understanding how telomere length is controlled has significant medical implications, especially in the fields of aging and cancer. Two recent systematic genome-wide surveys measuring the telomere length of deleted mutants in the yeast Saccharomyces cerevisiae have...

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Identifiers

PMID: 18319724
DOI: 10.1038/msb.2008.13
PMCID: PMC2290934

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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