Multidimensional Profiling of MRI-Negative Temporal Lobe Epilepsy Uncovers Distinct Phenotypes.

doi:10.1002/acn3.70349

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Article

Multidimensional Profiling of MRI-Negative Temporal Lobe Epilepsy Uncovers Distinct Phenotypes.

Annals of clinical and translational neurology - 1 Sept 2026

Ballerini Alice, Casarini Alessia, Biagioli Niccolò, Mirandola Laura, Ballotta Daniela, Summers Paul, Scolastico Simona, Madrassi Laura, Genovese Maurilio, Malagoli Marcella, Cantalupo Gaetano, Giovannini Giada, Pugnaghi Matteo, Orlandi Niccolò, Tassi Laura, Cuccarini Valeria, Aquino Domenico, Tartara Elena, Palesi Fulvia, Didato Giuseppe, Vitali Paolo, Meletti Stefano, Vaudano Anna Elisabetta

Abstract excerpt

OBJECTIVE: Although hippocampal sclerosis (TLE-HS) represents the most frequent cause of temporal lobe epilepsy (TLE), up to 30% of patients show no lesion on visual MRI inspection (TLE-MRIneg). These cases pose diagnostic and therapeutic challenges and are underrepresented in surgical series. We investigated whether TLE-MRIneg constitutes a distinct clinical and neuroanatomical entity compared to TLE-HS and...

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Topics

Humans
Epilepsy, Temporal Lobe
Female
Magnetic Resonance Imaging

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Male

Adult

Hippocampal Sclerosis

Phenotype

Atrophy

Middle Aged

Young Adult

Amygdala

Adolescent

Cerebral Cortical Thinning

Source

Open in PubMed Open full text

Identifiers

PMID: 41873635
DOI: 10.1002/acn3.70349
PMCID: PMC13394121

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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