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Fibroblast growth factor 13 is involved in the pathogenesis of temporal lobe epilepsy

13 Jan 2022

Abstract excerpt

BACKGROUND: Temporal lobe epilepsy (TLE) is the most common drug-resistant epilepsy in adults, with pathological mechanisms remaining to be fully elucidated. Fibroblast Growth Factor 13 (FGF13) encodes an intracellular protein involved in microtubule stabilization and regulation of voltage-gated sodium channels (VGSCs) function. FGF13 mutation has been identified in patients with inherent seizure, suggesting a...

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PMID: 35195262
DOI: 10.1093/cercor/bhac012

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