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Article

Simulation analysis of the stability mutants R96H of bacteriophage T4 lysozyme and I96A of barnase.

Ciba Foundation symposium - 1 Jan 1991

Karplus M, Prévost M, Tidor B, Wodak S

Abstract excerpt

Free energy simulation methods are used to analyse the effects of the mutation Arg-96----His on the stability of bacteriophage T4 lysozyme and of Ile-96----Ala on the stability of barnase. By use of thermodynamic integration, the contributions of specific interactions to the free energy change are evaluated. It is shown that a number of contributions that stabilize the wild-type or the mutant partially cancel in...

Topics

Bacterial Proteins
Enzyme Stability
Models, Chemical
Muramidase
Mutation
Protein Conformation
Ribonucleases
T-Phages
Thermodynamics

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 1814697
DOI: 10.1002/9780470514146.ch5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1814697-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Simulation analysis of the stability mutants R96H of bacteriophage T4 lysozyme and I96A of barnase.PMID 1814697Read ↗

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