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Article

Simulation analysis of the stability mutants R96H of bacteriophage T4 lysozyme and I96A of barnase.

Ciba Foundation symposium - 1 Jan 1991

Karplus M, Prévost M, Tidor B, Wodak S

Abstract excerpt

Free energy simulation methods are used to analyse the effects of the mutation Arg-96----His on the stability of bacteriophage T4 lysozyme and of Ile-96----Ala on the stability of barnase. By use of thermodynamic integration, the contributions of specific interactions to the free energy change are evaluated. It is shown that a number of contributions that stabilize the wild-type or the mutant partially cancel in...

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Identifiers

PMID: 1814697
DOI: 10.1002/9780470514146.ch5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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