Article
Mutant p53 targeting by the low molecular weight compound STIMA-1.
Molecular oncology - 1 Jun 2008
Zache Nicole, Lambert Jeremy M R, Rökaeus Nina, Shen Jinfeng, Hainaut Pierre, Bergman Jan, Wiman Klas G, Bykov Vladimir J N
Abstract excerpt
Reactivation of mutant p53 in human tumor cells should induce cell death by apoptosis and thus eliminate the tumor. Several small molecules that reactivate mutant p53 have been identified. Here we show that STIMA-1, a low molecular weight compound with some structural similarities to the previously identified molecule CP-31398, can stimulate mutant p53 DNA binding in vitro and induce expression of p53 target...
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