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Article

Functional role of Meox2 during the epithelial cytostatic response to TGF‐β

14 Mar 2007

Abstract excerpt

Transforming growth factor beta (TGF-beta) suppresses epithelial cell growth. We have identified a new target gene of the TGF-beta/Smad pathway, Meox2, encoding the homeodomain transcription factor that is known to regulate endothelial cell proliferation and muscle development. Knockdown of endogenous Meox2 by RNA interference prevented the TGF-beta1-induced cytostatic response. Moreover, ectopic Meox2 suppressed...

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PMID: 19383287
DOI: 10.1016/j.molonc.2007.02.002

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