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Article

p53-Independent Role of MDM2 in TGF-β1 Resistance

18 Dec 1998

Abstract excerpt

Transforming growth factor-beta (TGF-beta) inhibits cell proliferation, and acquisition of TGF-beta resistance has been linked to tumorigenesis. A genetic screen was performed to identify complementary DNAs that abrogated TGF-beta sensitivity in mink lung epithelial cells. Ectopic expression of murine double minute 2 rescued TGF-beta-induced growth arrest in a p53-independent manner by interference with...

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PMID: 9856953
DOI: 10.1126/science.282.5397.2270

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