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Article

Highly active, citrate inhibition resistant form of Aspergillus niger 6-phosphofructo-1-kinase encoded by a modified pfkA gene.

Journal of biotechnology - 12 Oct 2009

Capuder Maja, Solar Tina, Bencina Mojca, Legisa Matic

Abstract excerpt

In Aspergillus niger cells spontaneous posttranslational modification of 6-phosphofructo-1-kinase (PFK1) occurs. In a two step process the native enzyme (85kDa) is first cleaved to an inactive fragment (49kDa) that regains its activity after phosphorylation of the protein. The shorter PFK1 fragment exhibits changed kinetics, such as resistance to citrate inhibition. In order to avoid spontaneous complex...

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Identifiers

PMID: 19379783
DOI: 10.1016/j.jbiotec.2009.04.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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