Article
Genotyping methods to analyse polymorphisms in Toll-like receptors and disease.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2009
Khor Chiea-Chuen
Abstract excerpt
It is now well accepted that a significant genetic component governs host susceptibility to different infectious diseases. As the Toll-like receptors (TLRs), together with their co-receptors and their downstream signalling partners, play such a crucial role in pathogen recognition and subsequent activation of the host immune response, any genetic mutation (polymorphism) that alters the protein structure and in so...
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