Article
Efficient catalytic promiscuity for chemically distinct reactions.
Angewandte Chemie (International ed. in English) - 1 Jan 2009
Babtie Ann C, Bandyopadhyay Subhajit, Olguin Luis F, Hollfelder Florian
Abstract excerpt
High catalytic proficiencies observed for the native and promiscuous reaction of the Pseudomonas aeruginosa arylsulfatase (PAS; the picture shows transition states of the two substrates with corresponding binding constants K(tx)) suggest that the trade-off between high activity and tight specificity can be substantially relaxed.
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