Article
Synthesis and vaccine evaluation of the tumor-associated carbohydrate antigen RM2 from prostate cancer.
Journal of the American Chemical Society - 31 Jul 2013
Chuang Hong-Yang, Ren Chien-Tai, Chao Chung-An, Wu Chung-Yi, Shivatare Sachin S, Cheng Ting-Jen R, Wu Chung-Yi, Wong Chi-Huey
Abstract excerpt
We have successfully developed a [1+2+3] one-pot strategy to synthesize the RM2 antigen hexasaccharide that was proposed to be a prostate tumor antigen. The structure of the synthetic product was verified by NMR analysis and antibody binding assay using a glycan microarray. In addition, the synth...
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