Article
Extensive genotyping of the BDNF and NTRK2 genes define protective haplotypes against obsessive-compulsive disorder.
Biological psychiatry - 15 Mar 2008
Alonso Pino, Gratacòs Mónica, Menchón José M, Saiz-Ruiz Jerónimo, Segalàs Cinto, Baca-García Enrique, Labad Javier, Fernández-Piqueras José, Real Eva, Vaquero Concepción, Pérez Mercedes, Dolengevich Helen, González Juan R, Bayés Mónica, de Cid Rafael, Vallejo Julio, Estivill Xavier
Abstract excerpt
BACKGROUND: Family, twin and molecular studies provide increasing evidence for the importance of genetic factors in obsessive-compulsive disorder (OCD). Recent work suggests that brain-derived neurotrophic factor (BDNF) may be involved in OCD pathophysiology. We used a linkage disequilibrium (LD)-mapping approach to investigate the role that BDNF and its specific receptor neurotrophic tyrosine kinase receptor...
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