Article
Inhibitors of factor VIII in black patients with hemophilia.
The New England journal of medicine - 16 Apr 2009
Viel Kevin R, Ameri Afshin, Abshire Thomas C, Iyer Rathi V, Watts Raymond G, Lutcher Charles, Channell Cynthia, Cole Shelley A, Fernstrom Karl M, Nakaya Shelley, Kasper Carol K, Thompson Arthur R, Almasy Laura, Howard Tom E
Abstract excerpt
BACKGROUND: Black patients with hemophilia A (factor VIII deficiency) are twice as likely as white patients to produce inhibitors against factor VIII proteins given as replacement therapy. There are six wild-type factor VIII proteins, designated H1 through H6, but only two (H1 and H2) match the recombinant factor VIII products used clinically. H1 and H2 are found in all racial groups and are the only factor VIII...
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