Article
Mutational analysis of the HIV-1 auxiliary protein Vif identifies independent domains important for the physical and functional interaction with HIV-1 reverse transcriptase.
Nucleic acids research - 1 Jun 2009
Kataropoulou Alexandra, Bovolenta Chiara, Belfiore Amalia, Trabatti Sonia, Garbelli Anna, Porcellini Simona, Lupo Rossella, Maga Giovanni
Abstract excerpt
The HIV-1 accessory protein Vif plays a dual role: it counteracts the natural restriction factors APOBEC3G and 3F and ensures efficient retrotranscription of the HIV-1 RNA genome. We have previously shown that Vif can act as an auxiliary factor for HIV-1 reverse transcriptase (RT), increasing its rate of association to RNA or DNA templates. Here, by using seven different Vif mutants, we provide in vitro evidences...
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