Linkage analysis with dense SNP maps in isolated populations.

Abstract excerpt

OBJECTIVE: SNP maps are becoming the gold standard for genetic markers, even for linkage analyses. However, because of the density of SNPs on most high throughput platforms, the resulting significant linkage disequilibrium (LD) can bias classical nonparametric multipoint linkage analyses. This problem may be even stronger in population isolates where LD can extend over larger distances and with a more stochastic...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Algorithms
• Share to Genetic Linkage
• Share to Polymorphism, Single Nucleotide