Article
Differentiation of hereditary spastic paraparesis from primary lateral sclerosis in sporadic adult-onset upper motor neuron syndromes.
Archives of neurology - 1 Apr 2009
Brugman Frans, Veldink Jan H, Franssen Hessel, de Visser Marianne, de Jong J M B Vianney, Faber Carin G, Kremer Berry H P, Schelhaas H Jurgen, van Doorn Pieter A, Verschuuren Jan J G M, Bruyn Richard P M, Kuks Jan B M, Robberecht Wim, Wokke John H J, van den Berg Leonard H
Abstract excerpt
OBJECTIVE: To study whether clinical characteristics can differentiate sporadic presentations of hereditary spastic paraparesis (HSP) from primary lateral sclerosis (PLS). Differentiation between these diseases is important for genetic counseling and prognostication. DESIGN: Case series. SETTING: Tertiary referral center. PATIENTS: One hundred four Dutch patients with an adult-onset, sporadic upper motor neuron...
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