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Article

The clinical spectrum of primary lateral sclerosis.

Amyotrophic lateral sclerosis & frontotemporal degeneration - 1 Nov 2020

Barohn Richard J, Fink John K, Heiman-Patterson Terry, Huey Edward D, Murphy Jennifer, Statland Jeffrey M, Turner Martin R, Elman Lauren

Abstract excerpt

Primary lateral sclerosis is a distinct entity that has recently been classified as a "restricted phenotype" of ALS. It is characterized by a pattern of isolated upper motor neuron involvement that often begins in the legs and spreads diffusely. Distinction from other conditions requires careful consideration of clinical presentation and time course of disease. Mills' Syndrome is a rare unilateral variant of...

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PMID: 33602013
DOI: 10.1080/21678421.2020.1837178

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