Article
Polymorphism in PfMRP1 (Plasmodium falciparum multidrug resistance protein 1) amino acid 1466 associated with resistance to sulfadoxine-pyrimethamine treatment.
Antimicrobial agents and chemotherapy - 1 Jun 2009
Dahlström Sabina, Veiga M Isabel, Mårtensson Andreas, Björkman Anders, Gil J Pedro
Abstract excerpt
Sulfadoxine-pyrimethamine (SP) remains widely recommended for intermittent preventive treatment against Plasmodium falciparum malaria for pregnant women and infants in Africa. Resistance to SP is increasing and associated primarily with mutations in the P. falciparum dhfr (Pfdhfr) and Pfdhps gene...
Topics
- Animals
- Antimalarials
- Child
- Drug Combinations
- Genotype
- Haplotypes
- Humans
- Multidrug Resistance-Associated Proteins
- Plasmodium falciparum
- Polymorphism, Single Nucleotide
- Pyrimethamine
- Sulfadoxine