MICA-HLA-B haplotype diversity and linkage disequilibrium in a population of Jewish descent from Majorca (the Balearic Islands).

doi:10.1016/j.humimm.2009.04.005

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Article

MICA-HLA-B haplotype diversity and linkage disequilibrium in a population of Jewish descent from Majorca (the Balearic Islands).

Human immunology - 1 Jul 2009

Cambra Ana, Muñoz-Saá Iván, Crespí Catalina, Serra Antònia, Etxagibel Aitziber, Matamoros Núria, Milà Joan, Julià Maria Rosa

Abstract excerpt

The major histocompatibility complex class I chain-related A (MICA) gene is located 46 kb centromeric of human leukocyte antigen (HLA)-B and is highly polymorphic, similar to HLA genes. This allelic variation may influence the affinity of MICA molecules to their receptor on natural killer, gammadelta T and CD8+ T cells, NKG2D, and the immune response to organ transplantation and disease susceptibility. In the...

Topics

Gene Frequency
Genetic Variation
HLA-B Antigens
Haplotypes
Histocompatibility Antigens Class I
Humans
Jews
Linkage Disequilibrium
Polymorphism, Genetic
Spain
White People

Source

Open in PubMed

Identifiers

PMID: 19364518
DOI: 10.1016/j.humimm.2009.04.005

Genes

MICA

Provenance

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