Article
Apparent elimination of EIAV ancestral species in a long-term inapparent carrier.
Virology - 20 Jan 2006
Craigo Jodi K, Sturgeon Timothy J, Cook Sheila J, Issel Charles J, Leroux Caroline, Montelaro Ronald C
Abstract excerpt
Equine infectious anemia virus (EIAV) envelope variation produces newly dominant quasispecies with each sequential disease cycle; new populations arise, and previous plasma quasispecies, including the original inoculum, become undetectable. The question remains whether these ancestral variants exist in tissue reservoirs or if the immune system eliminates quasispecies from persistent infections. To examine this,...
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