Article
Functional proteomics identifies targets of phosphorylation by B-Raf signaling in melanoma.
Molecular cell - 10 Apr 2009
Old William M, Shabb John B, Houel Stephane, Wang Hong, Couts Kasey L, Yen Chia-Yu, Litman Elizabeth S, Croy Carrie H, Meyer-Arendt Karen, Miranda Jose G, Brown Robert A, Witze Eric S, Schweppe Rebecca E, Resing Katheryn A, Ahn Natalie G
Abstract excerpt
Melanoma and other cancers harbor oncogenic mutations in the protein kinase B-Raf, which leads to constitutive activation and dysregulation of MAP kinase signaling. In order to elucidate molecular determinants responsible for B-Raf control of cancer phenotypes, we present a method for phosphoprotein profiling, using negative ionization mass spectrometry to detect phosphopeptides based on their fragment ion...
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