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Article

Imaging Mass Spectrometry for the Classification of Melanoma Based on BRAF/NRAS Mutational Status.

International journal of molecular sciences - 7 Mar 2023

Casadonte Rita, Kriegsmann Mark, Kriegsmann Katharina, Streit Helene, Meliß Rolf Rüdiger, Müller Cornelia S L, Kriegsmann Joerg

Abstract excerpt

Mutations of the oncogenes v-raf murine sarcoma viral oncogene homolog B1 (BRAF) and neuroblastoma RAS viral oncogene homolog (NRAS) are the most frequent genetic alterations in melanoma and are mutually exclusive. BRAF V600 mutations are predictive for response to the two BRAF inhibitors vemurafenib and dabrafenib and the mitogen-activated protein kinase kinase (MEK) inhibitor trametinib. However, inter- and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36982192
DOI: 10.3390/ijms24065110
PMCID: PMC10049262

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