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Article

The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1.

Immunity - 17 Apr 2009

Thomas Paul G, Dash Pradyot, Aldridge Jerry R, Ellebedy Ali H, Reynolds Cory, Funk Amy J, Martin William J, Lamkanfi Mohamed, Webby Richard J, Boyd Kelli L, Doherty Peter C, Kanneganti Thirumala-Devi

Abstract excerpt

Virus-induced interlukin-1beta (IL-1beta) and IL-18 production in macrophages are mediated via caspase-1 pathway. Multiple microbial components, including viral RNA, are thought to trigger assembly of the cryopyrin inflammasome resulting in caspase-1 activation. Here, we demonstrated that Nlrp3(-/-) and Casp1(-/-) mice were more susceptible than wild-type mice after infection with a pathogenic influenza A virus....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to NLR Family, Pyrin Domain-Containing 3 Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 19362023
DOI: 10.1016/j.immuni.2009.02.006
PMCID: PMC2765464

Genes

NLRP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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