Article
Cytokine polymorphisms and severity of tubal damage in women with Chlamydia-associated infertility.
The Journal of infectious diseases - 1 May 2009
Ohman H, Tiitinen A, Halttunen M, Lehtinen M, Paavonen J, Surcel H-M
Abstract excerpt
Chronic inflammation induced by Chlamydia trachomatis can lead to tubal factor infertility (TFI). To investigate the genetic basis of chlamydial TFI and various manifestations of tubal damage, we studied functional polymorphisms in selected cytokine genes (IL-10 -1082 A/G, -819 T/C, and -592 A/C; IFN-gamma +874 T/A; TNF-alpha -308 G/A; TGF-beta1 codons 10 T/C and 25 G/C; and IL-6 -174 G/C) in 114 women with...
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