Article
Interruption of CXCL13-CXCR5 axis increases upper genital tract pathology and activation of NKT cells following chlamydial genital infection.
PloS one - 1 Jan 2012
Jiang Janina, Karimi Ouafae, Ouburg Sander, Champion Cheryl I, Khurana Archana, Liu Guangchao, Freed Amanda, Pleijster Jolein, Rozengurt Nora, Land Jolande A, Surcel Helja-Marja, Tiitinen Aila', Paavonen Jorma, Kronenberg Mitchell, Morré Servaas A, Kelly Kathleen A
Abstract excerpt
BACKGROUND: Regulation of immune responses is critical for controlling inflammation and disruption of this process can lead to tissue damage. We reported that CXCL13 was induced in fallopian tube tissue following C. trachomatis infection. Here, we examined the influence of the CXCL13-CXCR5 axis in chlamydial genital infection. METHODOLOGY AND PRINCIPAL FINDINGS: Disruption of the CXCL13-CXCR5 axis by injecting...
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