A common variant on chromosome 11q13 is associated with atopic dermatitis.

doi:10.1038/ng.347

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Article

A common variant on chromosome 11q13 is associated with atopic dermatitis.

Nature genetics - 1 May 2009

Esparza-Gordillo Jorge, Weidinger Stephan, Fölster-Holst Regina, Bauerfeind Anja, Ruschendorf Franz, Patone Giannino, Rohde Klaus, Marenholz Ingo, Schulz Florian, Kerscher Tamara, Hubner Norbert, Wahn Ulrich, Schreiber Stefan, Franke Andre, Vogler Rainer, Heath Simon, Baurecht Hansjörg, Novak Natalija, Rodriguez Elke, Illig Thomas, Lee-Kirsch Min-Ae, Ciechanowicz Andrzej, Kurek Michael, Piskackova Tereza, Macek Milan, Lee Young-Ae, Ruether Andreas

Abstract excerpt

We conducted a genome-wide association study in 939 individuals with atopic dermatitis and 975 controls as well as 270 complete nuclear families with two affected siblings. SNPs consistently associated with atopic dermatitis in both discovery sets were then investigated in two additional independent replication sets totalling 2,637 cases and 3,957 controls. Highly significant association was found with allele A...

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PMID: 19349984
DOI: 10.1038/ng.347

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