Article
Influence of IL17A polymorphisms (rs2275913 and rs3748067) on the susceptibility to ulcerative colitis.
Clinical and experimental medicine - 1 Nov 2013
Hayashi Ranji, Tahara Tomomitsu, Shiroeda Hisakazu, Saito Takashi, Nakamura Masakatsu, Tsutsumi Mikihiro, Shibata Tomoyuki, Arisawa Tomiyasu
Abstract excerpt
Interleukin-17A plays a role in tissue inflammation by inducing release of proinflammatory and neutrophil-mobilizing cytokines. We investigated the association between ulcerative colitis (UC) and polymorphisms of IL17A, rs2275913 (-197 G > A), and rs3748067 (*1249 C > T). The study was performed in 475 healthy subjects (controls) and 202 with UC (UC cases), including 113 controls and 64 UC cases from previous...
Topics
- 3' Untranslated Regions
- Adult
- Aged
- Colitis, Ulcerative
- Female
- Gene Frequency