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Article

Dynamic requirements for a functional protein hinge.

Journal of molecular biology - 20 Apr 2007

Kempf James G, Jung Ju-Yeon, Ragain Christina, Sampson Nicole S, Loria J Patrick

Abstract excerpt

The enzyme triosephosphate isomerase (TIM) is a model of catalytic efficiency. The 11 residue loop 6 at the TIM active site plays a major role in this enzymatic prowess. The loop moves between open and closed states, which facilitate substrate access and catalysis, respectively. The N and C-terminal hinges of loop 6 control this motion. Here, we detail flexibility requirements for hinges in a comparative solution...

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Identifiers

PMID: 17336327
DOI: 10.1016/j.jmb.2007.01.074
PMCID: PMC2203303

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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