Article
Gene prioritization based on biological plausibility over genome wide association studies renders new loci associated with type 2 diabetes.
Genetics in medicine : official journal of the American College of Medical Genetics - 1 May 2009
Sookoian Silvia, Gianotti Tomas Fernández, Schuman Mariano, Pirola Carlos Jose
Abstract excerpt
PURPOSE: We present an approach to prioritize single nucleotide polymorphisms for further follow-up in genome-wide association studies of type 2 diabetes. METHOD: The proposed method combines both the use of open data access from two type 2 diabetes-genome-wide association studies (granted by the Diabetes Genetics Initiative and the Welcome Trust Case Control Consortium) and the comprehensive analysis of...
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