Article
Mesenchymal stem cells in rheumatoid synovium: enumeration and functional assessment in relation to synovial inflammation level.
Annals of the rheumatic diseases - 1 Feb 2010
Jones E, Churchman S M, English A, Buch M H, Horner E A, Burgoyne C H, Reece R, Kinsey S, Emery P, McGonagle D, Ponchel F
Abstract excerpt
OBJECTIVE: Achieving joint regeneration in rheumatoid arthritis (RA) represents a future challenge. Autologous synovial mesenchymal stem cells (MSCs) could be therapeutically exploited. However, the inflammatory milieu in the RA synovium could adversely affect endogenous MSC function. To test this hypothesis, the frequency and multipotency of RA synovial MSCs was evaluated in relation to existing synovial...
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