Article
Mesenchymal stem cells in synovial fluid increase in number in response to synovitis and display more tissue-reparative phenotypes in osteoarthritis.
Stem cell research & therapy - 8 Sept 2023
Furuoka Hideto, Endo Kentaro, Sekiya Ichiro
Abstract excerpt
BACKGROUND: Synovial fluid mesenchymal stem cells (SF-MSCs) originate in the synovium and contribute to the endogenous repair of damaged intra-articular tissues. Here, we clarified the relationship between their numbers and joint structural changes during osteoarthritis (OA) progression and investigated whether SF-MSCs had phenotypes favorable for tissue repair, even in an OA environment. METHODS: Partial medial...
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