Article
E. coli cardiolipin synthase: function of N-terminal conserved residues.
Biochimica et biophysica acta - 1 Oct 2009
Quigley Bernard R, Tropp Burton E
Abstract excerpt
The E. coli cls open reading frame (ORF) predicts a 54.8 kDa polypeptide, whereas mature cardiolipin (CL) synthase is 46 kDa. The N-terminal region extending to residue 60 contains several conserved residues but is not essential for enzyme activity. A deletion mutant that is missing residues 2-60 produces a fully active protein. These findings raise the question of why several residues in a region that is not...
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