Article
Splice-variant- and stage-specific RNA editing of the Drosophila GABA receptor modulates agonist potency.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Apr 2009
Jones Andrew K, Buckingham Steven D, Papadaki Magdalini, Yokota Maiko, Sattelle Benedict M, Matsuda Kazuhiko, Sattelle David B
Abstract excerpt
The molecular diversity of many gene products functioning in the nervous system is enhanced by alternative splicing and adenosine-to-inosine editing of pre-mRNA. Using RDL, a Drosophila melanogaster GABA-gated ion channel, we examined the functional impact of RNA editing at several sites along with alternative splicing of more than one exon. We show that alternative splicing and RNA editing have a combined...
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